Targeting MEK in a Translational Model of Histiocytic Sarcoma. [electronic resource]
Producer: 20190910Description: 2439-2450 p. digitalISSN:- 1538-8514
- Animals
- Apoptosis -- drug effects
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dogs
- Down-Regulation -- drug effects
- Female
- Histiocytic Sarcoma -- drug therapy
- Liver -- drug effects
- MAP Kinase Signaling System -- drug effects
- Mice, Inbred NOD
- Mice, SCID
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Models, Biological
- Molecular Targeted Therapy
- Phosphatidylinositol 3-Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Pyridones -- pharmacology
- Pyrimidinones -- pharmacology
- Survival Analysis
- Translational Research, Biomedical
- Up-Regulation -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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