Small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy. [electronic resource]
Producer: 20190304Description: 14974-14988 p. digitalISSN:- 1083-351X
- Animals
- Basic Helix-Loop-Helix Transcription Factors -- chemistry
- Crystallography, X-Ray
- DNA Repair -- drug effects
- Dimerization
- Humans
- Mice
- Neoplasm Proteins -- chemistry
- Neoplasms -- drug therapy
- Protein Conformation -- drug effects
- Protein Multimerization
- Protein Subunits -- chemistry
- Small Molecule Libraries -- chemistry
- Transcription Factor TFIIH -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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