Triptolide induces p53-dependent cardiotoxicity through mitochondrial membrane permeabilization in cardiomyocytes. [electronic resource]
Producer: 20190314Description: 269-285 p. digitalISSN:- 1096-0333
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- toxicity
- Apoptosis -- drug effects
- Cell Line
- Diterpenes -- antagonists & inhibitors
- Epoxy Compounds -- antagonists & inhibitors
- Heart Diseases -- chemically induced
- Membrane Potential, Mitochondrial -- drug effects
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mitochondria, Heart -- drug effects
- Myocardium -- pathology
- Myocytes, Cardiac -- drug effects
- Phenanthrenes -- antagonists & inhibitors
- Reactive Oxygen Species -- metabolism
- Tumor Suppressor Protein p53 -- deficiency
- bcl-2-Associated X Protein -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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