Pharmacophore modeling for identification of anti-IGF-1R drugs and in-vitro validation of fulvestrant as a potential inhibitor. [electronic resource]
Producer: 20180806Description: e0196312 p. digitalISSN:- 1932-6203
- Antineoplastic Agents -- chemistry
- Breast Neoplasms -- drug therapy
- Carrier Proteins -- genetics
- Databases, Pharmaceutical
- Drug Evaluation, Preclinical
- Estradiol -- analogs & derivatives
- Estrogen Receptor Antagonists -- chemistry
- Estrogen Receptor alpha -- genetics
- Female
- Fulvestrant
- Gene Expression -- drug effects
- Humans
- Insulin Receptor Substrate Proteins -- genetics
- Ligands
- MCF-7 Cells
- Membrane Proteins
- Models, Chemical
- Models, Molecular
- Receptor, IGF Type 1
- Receptors, Somatomedin -- antagonists & inhibitors
- Signal Transduction -- drug effects
- User-Computer Interface
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Publication Type: Journal Article; Validation Study
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