SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways. [electronic resource]
Producer: 20180829Description: E3798-E3807 p. digitalISSN:- 1091-6490
- Animals
- Cells, Cultured
- Down-Regulation
- Gene Expression Regulation -- drug effects
- Gene Silencing
- HEK293 Cells
- HIV -- physiology
- Humans
- I-kappa B Kinase -- antagonists & inhibitors
- Immunity, Innate
- Inflammation -- immunology
- Interferon Regulatory Factor-7 -- antagonists & inhibitors
- Interferon-alpha -- biosynthesis
- Macrophages -- immunology
- Male
- Mice
- NF-KappaB Inhibitor alpha -- metabolism
- NF-kappa B -- metabolism
- Phosphorylation
- Protein Processing, Post-Translational
- Recombinant Proteins -- immunology
- SAM Domain and HD Domain-Containing Protein 1 -- physiology
- Sendai virus -- physiology
- Signal Transduction -- immunology
- THP-1 Cells
- Virus Diseases -- immunology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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