NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology. [electronic resource]
Producer: 20190225Description: 7733 p. digitalISSN:- 2045-2322
- Animals
- Biomarkers
- Cell Line
- Disease Models, Animal
- Enzyme Activation
- Gene Expression
- Humans
- Intracellular Space -- metabolism
- Male
- Mice
- Mice, Knockout
- Mice, Transgenic
- Models, Biological
- Mutation
- Nedd4 Ubiquitin Protein Ligases -- metabolism
- Polycystic Kidney, Autosomal Recessive -- genetics
- Protein Transport
- Rats
- Receptors, Cell Surface -- deficiency
- Signal Transduction
- rho GTP-Binding Proteins -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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