VEGFR-2 inhibitors and apoptosis inducers: synthesis and molecular design of new benzo[g]quinazolin bearing benzenesulfonamide moiety. [electronic resource]
Producer: 20190214Description: 893-907 p. digitalISSN:- 1475-6374
- Antineoplastic Agents -- chemical synthesis
- Apoptosis -- drug effects
- Breast -- cytology
- Caspase 3 -- metabolism
- Catalytic Domain
- Cell Cycle Checkpoints -- drug effects
- Cell Line
- Drug Screening Assays, Antitumor
- Enzyme Activation
- Humans
- Inhibitory Concentration 50
- MCF-7 Cells
- Molecular Docking Simulation
- Piperidines -- pharmacology
- Protein Kinase Inhibitors -- chemical synthesis
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Quinazolines -- chemical synthesis
- Spectrum Analysis -- methods
- Sulfonamides -- chemistry
- Vascular Endothelial Growth Factor Receptor-2 -- antagonists & inhibitors
- bcl-2-Associated X Protein -- metabolism
- Benzenesulfonamides
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Publication Type: Comparative Study; Journal Article
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