Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1α to modulate hypoxic responses in chondrocytes. [electronic resource]
Producer: 20180306Description: 127-138 p. digitalISSN:- 1873-3913
- Animals
- Autophagy -- drug effects
- Cell Hypoxia -- drug effects
- Chondrocytes -- cytology
- Homeodomain Proteins -- chemistry
- Humans
- Hydroxylation
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Lysosomes -- drug effects
- Mice, Transgenic
- Oxygen -- pharmacology
- Proline -- metabolism
- Protein Binding -- drug effects
- Protein Stability -- drug effects
- Proteolysis -- drug effects
- Sequestosome-1 Protein -- metabolism
- Transcription Factors -- chemistry
- Transcription, Genetic -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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