Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival. [electronic resource]
Producer: 20170830Description: 493-506 p. digitalISSN:- 1097-4164
- Animals
- Antineoplastic Agents -- pharmacology
- Brain Neoplasms -- drug therapy
- Bridged Bicyclo Compounds, Heterocyclic -- pharmacology
- Cell Cycle Proteins -- antagonists & inhibitors
- Cell Line, Tumor
- Drug Synergism
- F-Box Proteins -- genetics
- F-Box-WD Repeat-Containing Protein 7
- Feedback, Physiological
- Gene Expression Regulation, Neoplastic
- Humans
- Mice, Nude
- N-Myc Proto-Oncogene Protein -- antagonists & inhibitors
- Neuroblastoma -- drug therapy
- Neurons -- drug effects
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- Pteridines -- pharmacology
- RNA, Small Interfering -- genetics
- Signal Transduction
- Sulfonamides -- pharmacology
- Survival Analysis
- Transcription, Genetic
- Tumor Burden -- drug effects
- Ubiquitin-Protein Ligases -- genetics
- Xenograft Model Antitumor Assays
- Polo-Like Kinase 1
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Publication Type: Journal Article
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