Replication fork stability confers chemoresistance in BRCA-deficient cells. [electronic resource]
Producer: 20160824Description: 382-7 p. digitalISSN:- 1476-4687
- Animals
- Carrier Proteins -- genetics
- Cell Line, Tumor
- Cisplatin -- pharmacology
- DNA -- biosynthesis
- DNA Breaks, Double-Stranded
- DNA Damage -- drug effects
- DNA Helicases -- genetics
- DNA Repair -- drug effects
- DNA Repair Enzymes -- antagonists & inhibitors
- DNA Replication -- drug effects
- DNA-Binding Proteins -- antagonists & inhibitors
- Drug Resistance, Neoplasm -- drug effects
- Embryonic Stem Cells -- drug effects
- Female
- Gene Deletion
- Genes, BRCA1
- Genes, BRCA2
- Homologous Recombination
- MRE11 Homologue Protein
- Mice
- Neoplasms -- genetics
- Nuclear Proteins -- deficiency
- Poly (ADP-Ribose) Polymerase-1
- Poly(ADP-ribose) Polymerase Inhibitors -- pharmacology
- Poly(ADP-ribose) Polymerases -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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