Redoubling the ring size of an endomorphin-2 analog transforms a centrally acting mu-opioid receptor agonist into a pure peripheral analgesic. [electronic resource]
Producer: 20170206Description: 309-17 p. digitalISSN:- 1097-0282
- Amino Acid Sequence
- Analgesics -- chemical synthesis
- Analgesics, Opioid -- chemical synthesis
- Animals
- Binding Sites
- Biological Assay
- Blood-Brain Barrier -- drug effects
- Calcium -- metabolism
- Cyclization
- Dimerization
- Humans
- Injections, Intraventricular
- Male
- Mice
- Models, Molecular
- Molecular Docking Simulation
- Oligopeptides -- chemical synthesis
- Pain -- drug therapy
- Peptides, Cyclic -- chemical synthesis
- Protein Binding
- Receptors, Opioid, delta -- chemistry
- Receptors, Opioid, kappa -- chemistry
- Receptors, Opioid, mu -- agonists
- Structure-Activity Relationship
No physical items for this record
Publication Type: Journal Article
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