Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways. [electronic resource]
Producer: 20161230Description: 9742-58 p. digitalISSN:- 1949-2553
- Biological Transport -- drug effects
- Bone Density Conservation Agents -- pharmacology
- Bone Neoplasms -- drug therapy
- Cadherins -- metabolism
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Survival -- drug effects
- Diphosphonates -- pharmacology
- Diterpenes -- pharmacology
- Epithelial-Mesenchymal Transition -- drug effects
- Farnesol -- pharmacology
- Focal Adhesion Kinase 1 -- metabolism
- Focal Adhesion Protein-Tyrosine Kinases -- metabolism
- Humans
- Imidazoles -- pharmacology
- JNK Mitogen-Activated Protein Kinases -- metabolism
- MAP Kinase Signaling System -- drug effects
- Neoplasm Invasiveness -- pathology
- Nuclear Proteins -- metabolism
- Osteoporosis -- chemically induced
- Osteosarcoma -- drug therapy
- Phosphorylation -- drug effects
- Prenylation -- drug effects
- Proto-Oncogene Proteins pp60(c-src) -- metabolism
- Snail Family Transcription Factors -- metabolism
- Twist-Related Protein 1 -- metabolism
- Zoledronic Acid
- cdc42 GTP-Binding Protein -- metabolism
- p38 Mitogen-Activated Protein Kinases -- metabolism
- rho-Associated Kinases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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