mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy. [electronic resource]
Producer: 20160811Description: 15790-7 p. digitalISSN:- 1091-6490
- Animals
- Autophagy
- Blotting, Western
- Cells, Cultured
- HEK293 Cells
- Humans
- Hydroxymethylglutaryl-CoA Synthase -- metabolism
- Immunosuppressive Agents -- pharmacology
- Naphthyridines -- pharmacology
- Proteasome Endopeptidase Complex -- metabolism
- Proteolysis -- drug effects
- Sirolimus -- pharmacology
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Time Factors
- Ubiquitin -- metabolism
- Ubiquitination -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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