ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts. [electronic resource]
Producer: 20161107Description: 44061-71 p. digitalISSN:- 1949-2553
- Animals
- Base Sequence
- CRISPR-Associated Proteins -- genetics
- CRISPR-Cas Systems
- Cell Differentiation
- Cell Line, Tumor
- Cell Proliferation
- Clustered Regularly Interspaced Short Palindromic Repeats
- Codon, Nonsense
- Gene Expression Regulation, Leukemic
- Genetic Predisposition to Disease
- Heterografts
- Homozygote
- Humans
- Interleukin Receptor Common gamma Subunit -- deficiency
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- genetics
- Mice, Inbred NOD
- Mice, Knockout
- Mice, SCID
- Molecular Sequence Data
- Neoplasm Transplantation
- Phenotype
- Polycomb Repressive Complex 2 -- genetics
- Repressor Proteins -- genetics
- Time Factors
- Tumor Suppressor Proteins -- genetics
- Ubiquitin Thiolesterase -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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