The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression. [electronic resource]
Producer: 20170606Description: 1534-40 p. digitalISSN:- 1468-2060
- Adult
- Aged
- CD8-Positive T-Lymphocytes -- metabolism
- Cells, Cultured
- Core Binding Factor Alpha 3 Subunit -- biosynthesis
- Electrophoretic Mobility Shift Assay
- Gene Expression Regulation
- Genes, Reporter
- Genetic Predisposition to Disease
- Genotyping Techniques -- methods
- Humans
- Interferon Regulatory Factors -- metabolism
- Middle Aged
- Polymorphism, Single Nucleotide
- RNA, Messenger -- genetics
- Real-Time Polymerase Chain Reaction
- Spondylitis, Ankylosing -- genetics
- Transcription Factors -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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