Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome. [electronic resource]
Producer: 20151215Description: 1939-43 p. digitalISSN:- 1550-6606
- Animals
- Autoantibodies -- blood
- Autoimmune Diseases of the Nervous System -- genetics
- Cells, Cultured
- Disease Models, Animal
- Embryo, Mammalian -- cytology
- Exodeoxyribonucleases -- genetics
- Fibroblasts -- drug effects
- Gene Expression -- drug effects
- Humans
- Immunoblotting
- Inflammation -- genetics
- Interferon-beta -- genetics
- Interferons -- immunology
- Macrophages -- drug effects
- Mice, Inbred C57BL
- Mice, Knockout
- Nervous System Malformations -- genetics
- Nucleotides, Cyclic -- immunology
- Nucleotidyltransferases -- genetics
- Phosphoproteins -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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