Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21(Waf1/Cip1) mediated inhibition of Hh-Gli signaling. [electronic resource]
Producer: 20160520Description: 75-84 p. digitalISSN:- 1878-5875
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Breast Neoplasms -- drug therapy
- Cell Line
- Cell Transformation, Neoplastic -- drug effects
- Curcumin -- pharmacology
- Cyclin-Dependent Kinase Inhibitor p21 -- genetics
- Drug Synergism
- Epithelial Cells -- drug effects
- Female
- Hedgehog Proteins -- metabolism
- Humans
- Immunoblotting
- Mice, Inbred BALB C
- Microscopy, Fluorescence
- RNA Interference
- Resveratrol
- Signal Transduction -- drug effects
- Smoke
- Stilbenes -- pharmacology
- Nicotiana -- chemistry
- Transcription Factors -- genetics
- Xenograft Model Antitumor Assays
- Zinc Finger Protein GLI1
- bcl-2-Associated X Protein -- metabolism
- bcl-X Protein -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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