High concentration of insulin promotes apoptosis of primary cultured rat ovarian granulosa cells via its increase in extracellular HMGB1. [electronic resource]
Producer: 20150930Description: 271-7 p. digitalISSN:- 1933-7205
- Animals
- Apoptosis -- drug effects
- Case-Control Studies
- Cells, Cultured
- Dose-Response Relationship, Drug
- Female
- Granulosa Cells -- drug effects
- HMGB1 Protein -- blood
- Humans
- Insulin -- toxicity
- Insulin Resistance
- Polycystic Ovary Syndrome -- blood
- RNA Interference
- Rats, Sprague-Dawley
- Signal Transduction -- drug effects
- Time Factors
- Transfection
- Up-Regulation
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Publication Type: Journal Article
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