A cell-based high-throughput screen for novel chemical inducers of fetal hemoglobin for treatment of hemoglobinopathies. [electronic resource]
Producer: 20150527Description: e107006 p. digitalISSN:- 1932-6203
- Animals
- Antigens, CD34 -- metabolism
- Bone Marrow Cells -- drug effects
- Chromosomes, Artificial, Yeast
- Drug Discovery
- Drug Evaluation, Preclinical
- Erythroid Precursor Cells -- drug effects
- Fetal Hemoglobin -- biosynthesis
- Gene Expression Regulation -- drug effects
- Gene Targeting
- Genes, Reporter
- Genetic Loci
- Genetic Vectors -- genetics
- Hemoglobinopathies -- drug therapy
- High-Throughput Screening Assays
- Humans
- Mice
- Mice, Transgenic
- beta-Globins -- biosynthesis
- gamma-Globins -- biosynthesis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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