Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). [electronic resource]
Producer: 20140802Description: 12195-201 p. digitalISSN:- 1083-351X
- Alanine -- chemistry
- Amino Acid Motifs -- genetics
- Animals
- Binding Sites -- genetics
- Cells, Cultured
- Crystallography, X-Ray
- Glycine -- chemistry
- Guanosine Triphosphate -- chemistry
- HeLa Cells
- Humans
- Hydrolysis
- Mechanistic Target of Rapamycin Complex 1
- Mice
- Models, Molecular
- Monomeric GTP-Binding Proteins -- chemistry
- Multiprotein Complexes -- genetics
- Mutation
- Neuropeptides -- chemistry
- Phosphorylation
- Protein Binding -- genetics
- Protein Structure, Tertiary
- Ras Homolog Enriched in Brain Protein
- Ribosomal Protein S6 Kinases, 70-kDa -- metabolism
- Signal Transduction -- genetics
- TOR Serine-Threonine Kinases -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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