Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation. [electronic resource]
Producer: 20140220Description: 607-20 p. digitalISSN:- 1878-1551
- Actinin -- genetics
- Animals
- Blotting, Western
- Calpain -- physiology
- Cell Differentiation
- Cell Nucleus -- genetics
- Cell Proliferation
- Cell Transformation, Neoplastic -- metabolism
- Cells, Cultured
- Cytoskeleton -- metabolism
- Flow Cytometry
- GATA1 Transcription Factor -- genetics
- Humans
- Immunoprecipitation
- Leukemia -- metabolism
- Megakaryocytes -- metabolism
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Morphogenesis
- Mutation -- genetics
- Positive Transcriptional Elongation Factor B -- genetics
- Protein Binding
- RNA, Messenger -- genetics
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- Ribonucleoproteins, Small Nuclear -- genetics
- Transcription, Genetic
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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