Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ε-mediated zona occludens-1 phosphorylation at threonine 770/772. [electronic resource]
Producer: 20140407Description: 3148-63 p. digitalISSN:- 1083-351X
- Animals
- Eicosanoic Acids -- metabolism
- Endothelial Cells -- cytology
- Extracellular Signal-Regulated MAP Kinases -- genetics
- Human Umbilical Vein Endothelial Cells
- Humans
- Lipoxygenase -- genetics
- MAP Kinase Signaling System -- drug effects
- Mice
- Mice, Knockout
- Phosphorylation -- drug effects
- Protein Kinase C-epsilon -- genetics
- Threonine -- genetics
- Tight Junctions -- genetics
- Zonula Occludens-1 Protein -- genetics
- Zonula Occludens-2 Protein -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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