DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac. [electronic resource]
Producer: 20140224Description: 3093-3103 p. digitalISSN:- 0006-3002
- Active Transport, Cell Nucleus -- drug effects
- Animals
- Antigens, Neoplasm -- metabolism
- Cell Death -- drug effects
- Cell Line
- Cell Nucleus -- drug effects
- Cytoprotection -- drug effects
- DNA Damage
- DNA Topoisomerases, Type II -- metabolism
- DNA-Binding Proteins -- antagonists & inhibitors
- Doxorubicin -- pharmacology
- G2 Phase -- drug effects
- HSP90 Heat-Shock Proteins -- metabolism
- Humans
- Phosphorylation -- drug effects
- Protein Binding -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Pyrones -- pharmacology
- Quinolines -- pharmacology
- Rats
- S Phase -- drug effects
- Signal Transduction -- drug effects
- Topoisomerase II Inhibitors -- pharmacology
- Tumor Suppressor Protein p53 -- metabolism
- rac GTP-Binding Proteins -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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