Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model. [electronic resource]
Producer: 20140403Description: 131-7 p. digitalISSN:- 1460-2180
- Animals
- Aryl Hydrocarbon Hydroxylases -- genetics
- Carcinogens -- pharmacokinetics
- Cytochrome P-450 CYP2A6
- Cytochrome P450 Family 2
- DNA Adducts -- metabolism
- Guanine -- analogs & derivatives
- Humans
- Lung Neoplasms -- chemically induced
- Mice, Transgenic
- Microsomes -- drug effects
- Nitrosamines -- blood
- Pyridines -- pharmacokinetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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