Deubiquitinase inhibition of 19S regulatory particles by 4-arylidene curcumin analog AC17 causes NF-κB inhibition and p53 reactivation in human lung cancer cells. [electronic resource]
Producer: 20140401Description: 1381-92 p. digitalISSN:- 1538-8514
- Animals
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Curcumin -- analogs & derivatives
- Disease Models, Animal
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Female
- Humans
- Lung Neoplasms -- drug therapy
- NF-kappa B -- antagonists & inhibitors
- Proteasome Endopeptidase Complex -- metabolism
- Proteasome Inhibitors -- pharmacology
- Proteolysis -- drug effects
- Tumor Burden -- drug effects
- Tumor Suppressor Protein p53 -- agonists
- Ubiquitin-Specific Proteases -- antagonists & inhibitors
- Ubiquitination -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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