Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo. [electronic resource]
Producer: 20131025Description: 433-45 p. digitalISSN:- 1949-2553
- Animals
- Apoptosis -- drug effects
- Caspases
- Cell Cycle -- drug effects
- Cell Line
- Cell Line, Tumor
- Cell Survival -- drug effects
- Child
- Dose-Response Relationship, Drug
- Female
- HEK293 Cells
- Humans
- Immunoblotting
- Janus Kinase 2 -- antagonists & inhibitors
- Mice
- Mice, Nude
- Mice, SCID
- Neuroblastoma -- drug therapy
- Pyrazoles -- administration & dosage
- Pyrimidines -- administration & dosage
- STAT3 Transcription Factor -- metabolism
- Sarcoma -- drug therapy
- Signal Transduction -- drug effects
- Survival Analysis
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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