The HSP90 inhibitor NVP-AUY922-AG inhibits the PI3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells. [electronic resource]
Producer: 20130521Description: 57-67 p. digitalISSN:- 1365-2141
- Adult
- Aged
- Aged, 80 and over
- Annexin A5 -- metabolism
- Antineoplastic Agents -- administration & dosage
- Antineoplastic Combined Chemotherapy Protocols -- administration & dosage
- Apoptosis -- drug effects
- Caspase 3 -- metabolism
- Cytarabine -- administration & dosage
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor -- methods
- Drug Synergism
- Female
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- Humans
- I-kappa B Kinase -- drug effects
- Isoxazoles -- administration & dosage
- Leukemia, Myeloid, Acute -- drug therapy
- Male
- Middle Aged
- Neoplasm Proteins -- antagonists & inhibitors
- Phosphatidylinositol 3-Kinases -- drug effects
- Resorcinols -- administration & dosage
- Signal Transduction -- drug effects
- Tumor Cells, Cultured -- drug effects
- Young Adult
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Publication Type: Journal Article
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