Inhibition of transforming growth factor β1/Smad3 signaling decreases hypoxia-inducible factor-1α protein stability by inducing prolyl hydroxylase 2 expression in human periodontal ligament cells. [electronic resource]
Producer: 20140619Description: 1346-52 p. digitalISSN:- 1943-3670
- Adolescent
- Cell Culture Techniques
- Cells, Cultured
- Chronic Periodontitis -- metabolism
- Cycloheximide -- pharmacology
- Dose-Response Relationship, Drug
- Fibroblasts -- drug effects
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- antagonists & inhibitors
- Hypoxia-Inducible Factor-Proline Dioxygenases -- drug effects
- Isoquinolines -- pharmacology
- Male
- Periodontal Ligament -- cytology
- Phosphorylation
- Protein Synthesis Inhibitors -- pharmacology
- Pyridines -- pharmacology
- Pyrroles -- pharmacology
- Signal Transduction -- drug effects
- Smad3 Protein -- antagonists & inhibitors
- Time Factors
- Transforming Growth Factor beta1 -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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