Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3. [electronic resource]
Producer: 20130411Description: 1034-41 p. digitalISSN:- 1555-8576
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Aurora Kinase B
- Aurora Kinases
- Carboplatin -- administration & dosage
- Carcinoma, Ovarian Epithelial
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Down-Regulation -- drug effects
- Drug Synergism
- Female
- Histones -- genetics
- Humans
- Neoplasms, Glandular and Epithelial -- drug therapy
- Ovarian Neoplasms -- drug therapy
- Piperazines -- administration & dosage
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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