Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4. [electronic resource]
Producer: 20121025Description: 1095-106 p. digitalISSN:- 1528-0020
- Animals
- Apoptosis -- drug effects
- Boronic Acids -- administration & dosage
- Bortezomib
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cyclin-Dependent Kinase 4 -- antagonists & inhibitors
- Cyclin-Dependent Kinase 6 -- antagonists & inhibitors
- Cytotoxins -- administration & dosage
- Down-Regulation -- drug effects
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Interferon Regulatory Factors -- genetics
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Mice, Transgenic
- Multiple Myeloma -- drug therapy
- Protein Kinase Inhibitors -- administration & dosage
- Pyrazines -- administration & dosage
- Substrate Specificity
- Time Factors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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