Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression. [electronic resource]
Producer: 20130702Description: 202-14 p. digitalISSN:- 1873-7064
- Allosteric Regulation -- drug effects
- Analgesics -- pharmacology
- Animals
- Anti-Anxiety Agents -- pharmacology
- Antidepressive Agents -- adverse effects
- Behavior, Animal -- drug effects
- Benzamides -- adverse effects
- Calcium -- metabolism
- Depressive Disorder, Treatment-Resistant -- drug therapy
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical -- methods
- Excitatory Amino Acid Antagonists -- adverse effects
- Glutamic Acid -- pharmacology
- HEK293 Cells
- Humans
- Mice
- Pyridines -- adverse effects
- Radioligand Assay -- methods
- Rats
- Receptor, Metabotropic Glutamate 5
- Receptors, Metabotropic Glutamate -- antagonists & inhibitors
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Publication Type: Journal Article
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