The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer. [electronic resource]
Producer: 20130604Description: 471-8 p. digitalISSN:- 1476-5594
- Animals
- Cell Line, Tumor
- Cell Proliferation
- Cell Transformation, Neoplastic -- genetics
- Colonic Neoplasms -- enzymology
- Endopeptidases -- genetics
- Genes, Tumor Suppressor
- HCT116 Cells
- HEK293 Cells
- Humans
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Nuclear Proteins -- genetics
- Phosphoprotein Phosphatases -- genetics
- Protein Binding
- Protein Interaction Domains and Motifs
- Protein Isoforms
- Proto-Oncogene Proteins c-akt -- genetics
- Signal Transduction
- Ubiquitination
- Up-Regulation
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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