Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis. [electronic resource]
Producer: 20120606Description: 12455-68 p. digitalISSN:- 1083-351X
- Adaptor Proteins, Signal Transducing -- genetics
- Animals
- Apoptosis
- Autophagy
- Autophagy-Related Protein 5
- Autophagy-Related Proteins
- Caspase 3 -- metabolism
- Caspase 8 -- metabolism
- Cell Membrane -- enzymology
- Cell Survival -- drug effects
- Cells, Cultured
- Death Domain Receptor Signaling Adaptor Proteins -- physiology
- Enzyme Activation
- Fas-Associated Death Domain Protein -- metabolism
- Gene Knockout Techniques
- Heat-Shock Proteins -- genetics
- Humans
- Hydrazines -- pharmacology
- Leukemia, Myeloid, Acute
- Lysosomal Membrane Proteins -- metabolism
- Mice
- Microtubule-Associated Proteins -- genetics
- Mitochondria -- drug effects
- Phosphotransferases (Alcohol Group Acceptor) -- antagonists & inhibitors
- Protein Binding
- Protein Multimerization
- Protein Transport
- Pyrazoles -- pharmacology
- Sequestosome-1 Protein
- Tumor Cells, Cultured
- Ubiquitin-Conjugating Enzymes -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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