p38αMAPK interacts with and inhibits RARα: suppression of the kinase enhances the therapeutic activity of retinoids in acute myeloid leukemia cells. [electronic resource]
Producer: 20121119Description: 1850-61 p. digitalISSN:- 1476-5551
- Animals
- Antineoplastic Agents -- pharmacology
- Cell Differentiation -- drug effects
- Cell Line
- Cell Proliferation -- drug effects
- Chlorocebus aethiops
- Gene Expression Regulation, Leukemic
- Gene Silencing
- Humans
- Leukemia, Myeloid, Acute -- drug therapy
- Ligands
- Mice
- Mitogen-Activated Protein Kinase 14 -- antagonists & inhibitors
- Oncogene Proteins, Fusion -- genetics
- Protein Binding
- Protein Stability
- Receptors, Retinoic Acid -- genetics
- Retinoic Acid Receptor alpha
- Retinoids -- pharmacology
- Transcription, Genetic
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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