A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. [electronic resource]
Producer: 20120508Description: 3317-22 p. digitalISSN:- 1091-6490
- Amino Acid Sequence
- Animals
- Binding Sites
- Blood-Brain Barrier
- Crystallography, X-Ray
- Disks Large Homolog 4 Protein
- Drug Design
- Drug Evaluation, Preclinical
- Guanylate Kinases -- antagonists & inhibitors
- Humans
- Infarction, Middle Cerebral Artery -- complications
- Intracellular Signaling Peptides and Proteins -- antagonists & inhibitors
- Learning Disabilities -- etiology
- Male
- Membrane Proteins -- antagonists & inhibitors
- Mice
- Mice, Inbred C57BL
- Models, Molecular
- Molecular Sequence Data
- Molecular Targeted Therapy
- Movement Disorders -- etiology
- Neuroprotective Agents -- chemical synthesis
- Nuclear Magnetic Resonance, Biomolecular
- PDZ Domains -- drug effects
- Peptides -- chemical synthesis
- Postural Balance
- Protein Conformation
- Sensation Disorders -- etiology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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