A novel small molecule, (E)-5-(2,4-di-tert-butyl-6-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-5'-methyl-7,7'-dimethoxy-4,4'-bibenzo[d][1,3]dioxole-5,5'-dicarboxylate (7k), alleviates the development of D-galactosamine/lipopolysaccharide-induced acute liver failure by inhibiting macrophage infiltration and regulating cytokine expression. [electronic resource]
Producer: 20120504Description: 146-55 p. digitalISSN:- 1521-0103
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- toxicity
- Cell Line
- Cell Migration Inhibition -- drug effects
- Cell Movement -- drug effects
- Cytokines -- antagonists & inhibitors
- Dioxoles -- chemistry
- Down-Regulation -- drug effects
- Female
- Galactosamine -- toxicity
- Lipopolysaccharides -- toxicity
- Liver Failure, Acute -- chemically induced
- Macrophages -- drug effects
- Mice
- Mice, Inbred BALB C
- Thiazolidines -- chemistry
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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