Single-cell pharmacodynamic monitoring of S6 ribosomal protein phosphorylation in AML blasts during a clinical trial combining the mTOR inhibitor sirolimus and intensive chemotherapy. [electronic resource]
Producer: 20120628Description: 1716-25 p. digitalISSN:- 1557-3265
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
- Cytarabine -- therapeutic use
- Drug Administration Schedule
- Etoposide -- therapeutic use
- Female
- Humans
- Leukemia, Myeloid, Acute -- metabolism
- Male
- Middle Aged
- Mitoxantrone -- therapeutic use
- Phosphorylation
- Pilot Projects
- Ribosomal Protein S6 -- metabolism
- Signal Transduction -- drug effects
- Sirolimus -- therapeutic use
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
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Publication Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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