Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase I. [electronic resource]
Producer: 20111122Description: 4804-7 p. digitalISSN:- 1464-3405
- Bacterial Proteins -- antagonists & inhibitors
- Binding Sites -- drug effects
- Binding, Competitive -- drug effects
- Crystallography, X-Ray
- Enzyme Inhibitors -- chemistry
- Fatty Acid Synthases -- antagonists & inhibitors
- Magnetic Resonance Spectroscopy
- Models, Molecular
- Molecular Structure
- Mycobacterium tuberculosis -- enzymology
- NADP -- chemistry
- Pyrazinamide -- analogs & derivatives
- Stereoisomerism
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
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