Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo. [electronic resource]
Producer: 20111025Description: 3537-48 p. digitalISSN:- 1476-5594
- Animals
- Blotting, Western
- Carbazoles -- pharmacology
- Cell Differentiation -- genetics
- Cell Proliferation -- drug effects
- Cellular Senescence -- drug effects
- Cyclin D1 -- genetics
- Female
- Gene Expression Profiling
- Glioblastoma -- drug therapy
- Glycosides -- pharmacology
- Humans
- I-kappa B Kinase -- antagonists & inhibitors
- I-kappa B Proteins -- genetics
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- NF-kappa B -- antagonists & inhibitors
- Neural Stem Cells -- drug effects
- Nitriles -- pharmacology
- Oligonucleotide Array Sequence Analysis
- Protein Kinase Inhibitors -- pharmacology
- RNA Interference
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- drug effects
- Sulfones -- pharmacology
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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