Casopitant: in vitro data and SimCyp simulation to predict in vivo metabolic interactions involving cytochrome P450 3A4. [electronic resource]
Producer: 20110614Description: 363-72 p. digitalISSN:- 1521-009X
- Adult
- Cells, Cultured
- Computer Simulation
- Cytochrome P-450 CYP3A -- genetics
- Cytochrome P-450 CYP3A Inhibitors
- Drug Evaluation, Preclinical -- methods
- Drug Interactions
- Enzyme Induction -- drug effects
- Enzyme Inhibitors -- pharmacology
- Female
- Hepatocytes -- drug effects
- Humans
- Male
- Metabolic Clearance Rate -- drug effects
- Microsomes, Liver -- drug effects
- Middle Aged
- Models, Molecular
- Neurokinin-1 Receptor Antagonists
- Neurotransmitter Agents -- analysis
- Piperazines -- analysis
- Piperidines -- analysis
- Recombinant Proteins -- antagonists & inhibitors
- Young Adult
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Publication Type: Journal Article
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