Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q. [electronic resource]
Producer: 20110302Description: 942-51 p. digitalISSN:- 1083-351X
- Animals
- Calcium Signaling -- physiology
- Complement C5a -- metabolism
- GTP-Binding Protein alpha Subunits, Gq-G11 -- metabolism
- GTP-Binding Protein beta Subunits -- metabolism
- GTP-Binding Protein gamma Subunits -- metabolism
- Humans
- Macrophages -- metabolism
- Mice
- Mice, 129 Strain
- Mice, Inbred C57BL
- Mutagenesis
- NIH 3T3 Cells
- Phospholipase C beta -- genetics
- RNA, Small Interfering
- Receptors, Purinergic P2 -- metabolism
- Uridine Diphosphate -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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