Strain improvement of Streptomyces roseosporus for daptomycin production by rational screening of He-Ne laser and NTG induced mutants and kinetic modeling. [electronic resource]
Producer: 20110726Description: 729-43 p. digitalISSN:- 1559-0291
- Bioreactors -- microbiology
- Biotechnology -- methods
- Confidence Intervals
- Daptomycin -- biosynthesis
- Decanoic Acids -- pharmacology
- Drug Resistance, Fungal -- drug effects
- Fermentation -- drug effects
- Gene Expression Regulation, Fungal -- drug effects
- Genetic Testing
- Kinetics
- Lasers, Gas
- Methylnitronitrosoguanidine
- Microbial Viability -- drug effects
- Models, Biological
- Mutagenesis -- drug effects
- Mutation -- genetics
- Reproducibility of Results
- Reverse Transcriptase Polymerase Chain Reaction
- Streptomyces -- drug effects
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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