A multi-endpoint evaluation of cytochrome P450 1A2, 2B6 and 3A4 induction response in human hepatocyte cultures after treatment with β-naphthoflavone, phenobarbital and rifampicin. [electronic resource]
Producer: 20110404Description: 185-94 p. digitalISSN:- 1874-0758
- Aryl Hydrocarbon Hydroxylases -- biosynthesis
- Biological Assay -- standards
- Blotting, Western
- Cells, Cultured
- Cytochrome P-450 CYP1A2 -- biosynthesis
- Cytochrome P-450 CYP2B6
- Cytochrome P-450 CYP3A -- biosynthesis
- Dose-Response Relationship, Drug
- Endpoint Determination
- Enzyme Induction
- Hepatocytes -- drug effects
- Humans
- Oxidoreductases, N-Demethylating -- biosynthesis
- Phenobarbital -- pharmacology
- RNA, Messenger -- biosynthesis
- Reverse Transcriptase Polymerase Chain Reaction
- Rifampin -- pharmacology
- Substrate Specificity
- Time Factors
- beta-Naphthoflavone -- pharmacology
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Publication Type: Journal Article
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