Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways. [electronic resource]
Producer: 20110302Description: 2657-68 p. digitalISSN:- 1523-4681
- Animals
- Apoptosis -- drug effects
- Cell Line
- Cell Nucleus -- metabolism
- Culture Media, Conditioned -- pharmacology
- Cyclic AMP-Dependent Protein Kinases -- metabolism
- Dexamethasone -- pharmacology
- Dinoprostone -- metabolism
- Glucocorticoids -- pharmacology
- Glycogen Synthase Kinase 3 -- metabolism
- Glycogen Synthase Kinase 3 beta
- Indomethacin -- pharmacology
- Lithium Chloride -- pharmacology
- Mice
- Models, Biological
- Osteocytes -- cytology
- Phosphatidylinositol 3-Kinase
- Protective Agents -- pharmacology
- Protein Stability -- drug effects
- Protein Transport -- drug effects
- Proto-Oncogene Proteins c-akt -- metabolism
- Receptors, Prostaglandin E, EP2 Subtype -- metabolism
- Receptors, Prostaglandin E, EP4 Subtype -- metabolism
- Rheology -- drug effects
- Signal Transduction -- drug effects
- Stress, Mechanical
- beta Catenin -- metabolism
No physical items for this record
Publication Type: Journal Article; Research Support, N.I.H., Extramural
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