Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation. [electronic resource]
Producer: 20100427Description: 521-30 p. digitalISSN:- 1468-3288
- ATP Binding Cassette Transporter, Subfamily B -- genetics
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Bile -- metabolism
- Bile Acids and Salts -- biosynthesis
- Bile Ducts -- drug effects
- Cell Proliferation -- drug effects
- Cells, Cultured
- Cholangitis, Sclerosing -- drug therapy
- Curcumin -- pharmacology
- Drug Evaluation, Preclinical -- methods
- Epithelial Cells -- drug effects
- Fibroblasts -- drug effects
- Inflammation Mediators -- metabolism
- Liver Cirrhosis, Experimental -- drug therapy
- Male
- Mice
- Mice, Knockout
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- PPAR gamma -- metabolism
- Signal Transduction -- drug effects
- ATP-Binding Cassette Sub-Family B Member 4
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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