Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs. [electronic resource]
Producer: 20100608Description: 123-34 p. digitalISSN:- 1879-1301
- Anti-Inflammatory Agents -- chemical synthesis
- Cells, Cultured
- Class I Phosphatidylinositol 3-Kinases
- Class Ib Phosphatidylinositol 3-Kinase
- Drug Discovery
- Enzyme Inhibitors -- chemical synthesis
- Humans
- Isoenzymes -- antagonists & inhibitors
- Lipopolysaccharides -- toxicity
- Lymphocyte Activation
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Quinazolinones -- chemical synthesis
- Signal Transduction
- Tumor Necrosis Factor-alpha -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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