Increased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice. [electronic resource]
Producer: 20100225Description: 2540-56 p. digitalISSN:- 1525-2191
- Animals
- Cathepsin B -- metabolism
- Cathepsin D -- metabolism
- Cerebellum -- metabolism
- Cholesterol -- metabolism
- Fluorescent Antibody Technique
- Hippocampus -- metabolism
- Immunoblotting
- Intracellular Signaling Peptides and Proteins
- Lysosomes -- enzymology
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- Microscopy, Electron, Transmission
- Nerve Degeneration -- enzymology
- Neurons -- enzymology
- Niemann-Pick C1 Protein
- Niemann-Pick Disease, Type C -- enzymology
- Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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