MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa. [electronic resource]
Producer: 20100128Description: 1588-99 p. digitalISSN:- 1530-0285
- Adult
- Aged
- Aged, 80 and over
- Australia
- Carcinoma -- enzymology
- Chromosomes, Human, Pair 10
- Colorectal Neoplasms -- enzymology
- Cyclin-Dependent Kinase Inhibitor p16 -- genetics
- DNA Methylation
- DNA Modification Methylases -- genetics
- DNA Repair Enzymes -- genetics
- Epigenesis, Genetic
- Female
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Gene Frequency
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Immunohistochemistry
- Intestinal Mucosa -- enzymology
- Male
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Staging
- Odds Ratio
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- Prospective Studies
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins p21(ras)
- Tumor Suppressor Proteins -- genetics
- ras Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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