The glycogen synthase kinase inhibitor 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763) is a partial agonist of the aryl hydrocarbon receptor. [electronic resource]
Producer: 20091019Description: 1576-80 p. digitalISSN:- 1521-009X
- Animals
- Aryl Hydrocarbon Receptor Nuclear Translocator -- metabolism
- Basic Helix-Loop-Helix Transcription Factors
- Cell Line, Tumor
- Cytochrome P-450 CYP1A1 -- biosynthesis
- Dose-Response Relationship, Drug
- Drug Partial Agonism
- Enzyme Induction
- Glycogen Synthase Kinase 3 -- antagonists & inhibitors
- Glycogen Synthase Kinase 3 beta
- Hepatocytes -- drug effects
- Indoles -- pharmacology
- Male
- Maleimides -- pharmacology
- Mice
- Mice, Inbred C3H
- Mice, Knockout
- Polychlorinated Dibenzodioxins -- pharmacology
- Promoter Regions, Genetic -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- RNA, Messenger -- biosynthesis
- Receptors, Aryl Hydrocarbon -- agonists
- Signal Transduction -- drug effects
- Transcriptional Activation -- drug effects
- Wnt Proteins -- metabolism
- Wnt3 Protein
- beta Catenin -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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