Targeting DNA repair in chronic lymphocytic leukemia cells with a novel acyclic nucleotide analogue, GS-9219. [electronic resource]
Producer: 20090707Description: 3760-9 p. digitalISSN:- 1078-0432
- Alanine -- analogs & derivatives
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- genetics
- Cell Survival -- drug effects
- Chromatography, High Pressure Liquid
- DNA Damage
- DNA Repair -- drug effects
- DNA, Neoplasm -- chemistry
- Dose-Response Relationship, Drug
- Guanine -- analogs & derivatives
- Humans
- Immunoblotting
- Leukemia, Lymphocytic, Chronic, B-Cell -- genetics
- Models, Biological
- Molecular Structure
- Organophosphorus Compounds -- chemistry
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Purines -- chemistry
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- drug effects
- Tumor Cells, Cultured
- Ultraviolet Rays
- bcl-2-Associated X Protein -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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